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Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
Colley, Caroline S; Popovic, Bojana; Sridharan, Sudharsan; Debreczeni, Judit E; Hargeaves, David; Fung, Michael; An, Ling-Ling; Edwards, Bryan; Arnold, Joanne; England, Elizabeth; Eghobamien, Laura; Sivars, Ulf; Flavell, Liz; Renshaw, Jonathan; Wickson, Kate; Warrener, Paul; Zha, Jingying; Bonnell, Jessica; Woods, Rob; Wilkinson, Trevor; Dobson, Claire; Vaughan, Tristan J.
Afiliação
  • Colley CS; a Antibody Discovery and Protein Engineering, MedImmune Ltd , Cambridge , UK.
  • Popovic B; a Antibody Discovery and Protein Engineering, MedImmune Ltd , Cambridge , UK.
  • Sridharan S; a Antibody Discovery and Protein Engineering, MedImmune Ltd , Cambridge , UK.
  • Debreczeni JE; b Discovery Sciences, AstraZeneca R&D , Cambridge , UK.
  • Hargeaves D; b Discovery Sciences, AstraZeneca R&D , Cambridge , UK.
  • Fung M; c Respiratory, Inflammation and Autoimmunity, MedImmune LLC , Gaithersburg , MD , USA.
  • An LL; c Respiratory, Inflammation and Autoimmunity, MedImmune LLC , Gaithersburg , MD , USA.
  • Edwards B; a Antibody Discovery and Protein Engineering, MedImmune Ltd , Cambridge , UK.
  • Arnold J; a Antibody Discovery and Protein Engineering, MedImmune Ltd , Cambridge , UK.
  • England E; a Antibody Discovery and Protein Engineering, MedImmune Ltd , Cambridge , UK.
  • Eghobamien L; d Respiratory, Inflammation and Autoimmunity, MedImmune Ltd , Cambridge , UK.
  • Sivars U; e Translational Biology, IMED RIA Biotech Unit , AstraZeneca , Gothenburg , Sweden.
  • Flavell L; b Discovery Sciences, AstraZeneca R&D , Cambridge , UK.
  • Renshaw J; b Discovery Sciences, AstraZeneca R&D , Cambridge , UK.
  • Wickson K; b Discovery Sciences, AstraZeneca R&D , Cambridge , UK.
  • Warrener P; f Infectious Diseases, MedImmune LLC , Gaithersburg , MD , USA.
  • Zha J; f Infectious Diseases, MedImmune LLC , Gaithersburg , MD , USA.
  • Bonnell J; f Infectious Diseases, MedImmune LLC , Gaithersburg , MD , USA.
  • Woods R; g Antibody Discovery and Protein Engineering, MedImmune LLC , Gaithersburg , MD , USA.
  • Wilkinson T; a Antibody Discovery and Protein Engineering, MedImmune Ltd , Cambridge , UK.
  • Dobson C; a Antibody Discovery and Protein Engineering, MedImmune Ltd , Cambridge , UK.
  • Vaughan TJ; a Antibody Discovery and Protein Engineering, MedImmune Ltd , Cambridge , UK.
MAbs ; 10(1): 104-117, 2018 01.
Article em En | MEDLINE | ID: mdl-28952876

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complemento C5a / Receptores de Quimiocinas / Receptor da Anafilatoxina C5a / Anticorpos Monoclonais / Afinidade de Anticorpos Limite: Humans Idioma: En Revista: MAbs Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complemento C5a / Receptores de Quimiocinas / Receptor da Anafilatoxina C5a / Anticorpos Monoclonais / Afinidade de Anticorpos Limite: Humans Idioma: En Revista: MAbs Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido