[Hyponatremia in a 58-year-old female patient with EGFR-positive lung adenocarcinoma]. / Hyponatriämie bei einer 58-jährigen Patientin mit einem EGFR-positiven pulmonalen Adenokarzinom.
Internist (Berl)
; 59(4): 384-387, 2018 Apr.
Article
em De
| MEDLINE
| ID: mdl-28980030
ABSTRACT
The case of a 58-year old female patient with epidermal growth factor-positive pulmonary adenocarcinoma treated with the tyrosine kinase inhibitor afatinib is reported. After several months of first-line therapy the patient developed severe hyponatremia and tumor reassessment revealed a progressive course of the lung cancer. Rebiopsy showed transformation of the tumor into small-cell lung cancer. Therapy with afatinib was stopped immediately and platin-based chemotherapy was started. This case shows that tumor transformation under tyrosine kinase inhibitor therapy from non-small-cell into small-cell lung cancer can occur in rare cases.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes Paraneoplásicas
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Adenocarcinoma de Pulmão
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Afatinib
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Hiponatremia
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Neoplasias Pulmonares
Tipo de estudo:
Diagnostic_studies
Idioma:
De
Revista:
Internist (Berl)
Ano de publicação:
2018
Tipo de documento:
Article