Synthesis and cholinesterase inhibitory activity study of new piperidone grafted spiropyrrolidines.

Basiri, Alireza; Abd Razik, Basma M; Ezzat, Mohammed Oday; Kia, Yalda; Kumar, Raju Suresh; Almansour, Abdulrahman I; Arumugam, Natarajan; Murugaiyah, Vikneswaran

Basiri, Alireza; Abd Razik, Basma M; Ezzat, Mohammed Oday; Kia, Yalda; Kumar, Raju Suresh; Almansour, Abdulrahman I; Arumugam, Natarajan; Murugaiyah, Vikneswaran.

Afiliação

Basiri A; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, United States.
Abd Razik BM; College of Pharmacy, Al-Mustansiriyah University, 10001 Baghdad, Iraq.
Ezzat MO; College of Education for Women, University of Anbar, 31001 Ramadi, Anbar, Iraq.
Kia Y; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
Kumar RS; Department of Chemistry, College of Sciences, King Saud University, PO Box 2455, Riyadh, Saudi Arabia. Electronic address: sraju@ksu.edu.sa.
Almansour AI; Department of Chemistry, College of Sciences, King Saud University, PO Box 2455, Riyadh, Saudi Arabia.
Arumugam N; Department of Chemistry, College of Sciences, King Saud University, PO Box 2455, Riyadh, Saudi Arabia.
Murugaiyah V; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia. Electronic address: dr.Murugaiyah@gmail.com.

Bioorg Chem ; 75: 210-216, 2017 12.

Article em En | MEDLINE | ID: mdl-28987876

Assuntos

Acetilcolinesterase/química; Butirilcolinesterase/química; Inibidores da Colinesterase/síntese química; Piperidonas/química; Pirrolidinas/química; Acetilcolinesterase/metabolismo; Sítios de Ligação; Butirilcolinesterase/metabolismo; Domínio Catalítico; Inibidores da Colinesterase/química; Inibidores da Colinesterase/metabolismo; Inibidores da Colinesterase/farmacologia; Ativação Enzimática/efeitos dos fármacos; Concentração Inibidora 50; Líquidos Iônicos/química; Simulação de Acoplamento Molecular; Piperidonas/farmacologia; Pirrolidinas/síntese química; Pirrolidinas/metabolismo; Pirrolidinas/farmacologia

Palavras-chave

AChE and BChE activities; Ionic liquid; Molecular docking; Spiropyrrolidines

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidonas / Acetilcolinesterase / Pirrolidinas / Butirilcolinesterase / Inibidores da Colinesterase Idioma: En Revista: Bioorg Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google