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Possible pro-inflammatory role of heparin-binding epidermal growth factor-like growth factor in the active phase of systemic sclerosis.
Hirabayashi, Megumi; Asano, Yoshihide; Yamashita, Takashi; Miura, Shunsuke; Nakamura, Kouki; Taniguchi, Takashi; Saigusa, Ryosuke; Takahashi, Takehiro; Ichimura, Yohei; Miyagawa, Takuya; Yoshizaki, Ayumi; Miyagaki, Tomomitsu; Sugaya, Makoto; Sato, Shinichi.
Afiliação
  • Hirabayashi M; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Asano Y; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Yamashita T; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Miura S; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Nakamura K; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Taniguchi T; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Saigusa R; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Takahashi T; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Ichimura Y; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Miyagawa T; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Yoshizaki A; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Miyagaki T; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Sugaya M; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Sato S; Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
J Dermatol ; 45(2): 182-188, 2018 Feb.
Article em En | MEDLINE | ID: mdl-29044628
ABSTRACT
Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family growth factors, which affects multiple aspects of the wound healing process such as epithelialization, wound contraction and angiogenesis. In our study, we measured the serum HB-EGF levels of 51 systemic sclerosis (SSc) patients, which showed a significant increase compared with those of 20 normal subjects. Further analysis revealed a positive correlation between the HB-EGF level and pulmonary ground-glass score but no correlation between the former and pulmonary fibrosis score. Other findings include a significant increase of serum sialylated carbohydrate antigen KL-6 levels and significant shortness of disease duration in the diffuse cutaneous SSc patients with elevated HB-EGF levels; and significantly higher HB-EGF levels in the presence of Raynaud's phenomenon, in that of telangiectasia, and in the absence of contracture of phalanges in all SSc patients. We then evaluated HB-EGF mRNA levels of fibroblasts harvested from skin samples of the SSc patients and those of foreskin-derived fibroblasts treated with transforming growth factor-ß, both of which were significantly higher than each control. In conclusion, we speculate that HB-EGF plays a pro-inflammatory role in the active skin and lung lesions of SSc.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Escleroderma Sistêmico / Pele / Fator de Crescimento Semelhante a EGF de Ligação à Heparina / Pulmão Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Dermatol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Escleroderma Sistêmico / Pele / Fator de Crescimento Semelhante a EGF de Ligação à Heparina / Pulmão Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Dermatol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão