Roles of Mifepristone on the Regulation of Cytotoxic Lymphocytes and Regulatory T Cells.
Gynecol Obstet Invest
; 82(6): 533-537, 2017.
Article
em En
| MEDLINE
| ID: mdl-29080885
ABSTRACT
OBJECTIVE:
To investigate the immunologic function of mifepristone, which acts as a contraceptive drug at the level of the decidua.SETTING:
In our hospital, 60 women (less than 63 days of amenorrhea) volunteered to terminate their pregnancies by the uterine suction evacuation method. Immunohistochemically, the transcription factor forkhead box P3 and granzyme B staining were performed to identify regulatory T cells and cytotoxic lymphocytes (CLs) in all operational subjects. CD8 (cytotoxic T cells marker) and CD56 (natural killer cells marker) staining were further performed in order to characterize the CLs subpopulations.RESULT:
A significantly increased number of CLs was found in the decidua treated with mifepristone.CONCLUSION:
Mifepristone increases the expression of CLs in the decidua, and it provides new insights into the immunologic function of mifepristone as a drug used for pregnancy termination.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Abortivos Esteroides
/
Mifepristona
/
Linfócitos T Reguladores
/
Decídua
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Gynecol Obstet Invest
Ano de publicação:
2017
Tipo de documento:
Article