Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer.

Basudhar, Debashree; Glynn, Sharon A; Greer, Madison; Somasundaram, Veena; No, Jae Hong; Scheiblin, David A; Garrido, Pablo; Heinz, William F; Ryan, Aideen E; Weiss, Jonathan M; Cheng, Robert Y S; Ridnour, Lisa A; Lockett, Stephen J; McVicar, Daniel W; Ambs, Stefan; Wink, David A

Basudhar, Debashree; Glynn, Sharon A; Greer, Madison; Somasundaram, Veena; No, Jae Hong; Scheiblin, David A; Garrido, Pablo; Heinz, William F; Ryan, Aideen E; Weiss, Jonathan M; Cheng, Robert Y S; Ridnour, Lisa A; Lockett, Stephen J; McVicar, Daniel W; Ambs, Stefan; Wink, David A.

Afiliação

Basudhar D; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Glynn SA; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Greer M; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway H91 TK33, Ireland.
Somasundaram V; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
No JH; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Scheiblin DA; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Garrido P; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. for the National Cancer Institute, National Institutes of Health Frederick, MD 21702.
Heinz WF; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway H91 TK33, Ireland.
Ryan AE; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. for the National Cancer Institute, National Institutes of Health Frederick, MD 21702.
Weiss JM; Discipline of Pharmacology and Therapeutics, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway H91 TK33, Ireland.
Cheng RYS; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Ridnour LA; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Lockett SJ; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
McVicar DW; Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. for the National Cancer Institute, National Institutes of Health Frederick, MD 21702.
Ambs S; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Wink DA; Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Proc Natl Acad Sci U S A ; 114(49): 13030-13035, 2017 12 05.

Article em En | MEDLINE | ID: mdl-29087320

Assuntos

Neoplasias da Mama/genética; Ciclo-Oxigenase 2/genética; Regulação Neoplásica da Expressão Gênica; Óxido Nítrico Sintase Tipo II/genética; Receptores de Estrogênio/genética; Neoplasias de Mama Triplo Negativas/genética; Animais; Aspirina/farmacologia; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/mortalidade; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Ciclo-Oxigenase 2/metabolismo; Dinoprostona/metabolismo; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Retroalimentação Fisiológica; Feminino; Guanidinas/farmacologia; Humanos; Indometacina/farmacologia; Camundongos; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo; Prognóstico; Modelos de Riscos Proporcionais; Receptores de Estrogênio/deficiência; Transdução de Sinais; Fator 2 Associado a Receptor de TNF/genética; Fator 2 Associado a Receptor de TNF/metabolismo; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Neoplasias de Mama Triplo Negativas/mortalidade; Neoplasias de Mama Triplo Negativas/patologia; Carga Tumoral/efeitos dos fármacos; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

COX2; NOS2; PGE2; breast cancer; nitric oxide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Receptores de Estrogênio / Regulação Neoplásica da Expressão Gênica / Ciclo-Oxigenase 2 / Óxido Nítrico Sintase Tipo II / Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article

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