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Structure determination of two new C21 steroidal glycosides from Cynanchum komarovii.
Zhao, Dan; Tang, Ming-Xu; Su, Shan-Shan; Lu, Xiao-Jie; Wang, Yu-Bo; Chen, Shao-Fei; Wang, Hai-Feng; Chen, Gang; Pei, Yue-Hu.
Afiliação
  • Zhao D; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Tang MX; b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Su SS; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Lu XJ; b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Wang YB; c Testing Laboratory, Qinghai Entry Exit Inspection and Quarantine Bureau , Xining 810000 , China.
  • Chen SF; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Wang HF; b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Chen G; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Pei YH; b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
J Asian Nat Prod Res ; 20(9): 852-859, 2018 Sep.
Article em En | MEDLINE | ID: mdl-29099237
ABSTRACT
Two new 13,1414,15-disecopregnane-type C21 steroidal glycosides, namely komarosides R (1) and S (2), along with four known compounds (3-6), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. Compounds 1 and 2 showed potent inhibitory activities against human leukemia cell line (HL-60) with IC50 values being 6.2 and 17.6 µM, respectively, compared to the positive control 5-fluorouracil (6.4 µM).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fitosteróis / Cynanchum / Glicosídeos / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fitosteróis / Cynanchum / Glicosídeos / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China