The limbic and neocortical contribution of α-synuclein, tau, and amyloid ß to disease duration in dementia with Lewy bodies.
Alzheimers Dement
; 14(3): 330-339, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29100980
ABSTRACT
INTRODUCTION:
We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and amyloid ß (Aß) to duration of illness in dementia with Lewy bodies (DLB).METHODS:
Quantitative digital pathology of limbic and neocortical α-synuclein, tau, and Aß was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration.RESULTS:
Patients with diffuse Lewy body disease had more severe pathology of each type and a shorter duration of illness than individuals with transitional Lewy body disease. The three pathologies accounted for 25% of the total variance of duration of illness, with 19% accounted for by α-synuclein alone or in combination with tau and Aß. When the diffuse Lewy body disease group was examined separately, α-synuclein deposition significantly exceeded that of tau and Aß. In this model, 20% of 24% total variance in the model for duration of illness was accounted for independently by α-synuclein.DISCUSSION:
In DLB, α-synuclein is an important predictor of disease duration, both independently and synergistically with tau and Aß.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
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Proteínas tau
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Neocórtex
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Doença por Corpos de Lewy
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Alfa-Sinucleína
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Sistema Límbico
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2018
Tipo de documento:
Article