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Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE.
Raimondo, Joseph V; Heinemann, Uwe; de Curtis, Marco; Goodkin, Howard P; Dulla, Chris G; Janigro, Damir; Ikeda, Akio; Lin, Chou-Ching K; Jiruska, Premysl; Galanopoulou, Aristea S; Bernard, Christophe.
Afiliação
  • Raimondo JV; Division of Cell Biology, Department of Human Biology, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  • Heinemann U; Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • de Curtis M; Epilepsy and Experimental Neurophysiology Unit, The Foundation of the Carlo Besta Neurological Institute, Milan, Italy.
  • Goodkin HP; Departments of Neurology and Pediatrics, University of Virginia, Charlottesville, Virginia, U.S.A.
  • Dulla CG; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, U.S.A.
  • Janigro D; Flocel Inc., Cleveland, Ohio, U.S.A.
  • Ikeda A; Case Western Reserve University, Cleveland, Ohio, U.S.A.
  • Lin CK; Department of Epilepsy, Movement Disorders, and Physiology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.
  • Jiruska P; Department of Neurology, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan.
  • Galanopoulou AS; Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
  • Bernard C; Laboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology, Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Einstein/Montefiore Epilepsy Center, Montefiore Medical Center, Bronx, New York, U.S.A.
Epilepsia ; 58 Suppl 4: 40-52, 2017 11.
Article em En | MEDLINE | ID: mdl-29105075
ABSTRACT
In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous in vitro methodologies utilized in epilepsy research. We provide support for the inclusion of detailed descriptions of techniques, including often ignored parameters with unpredictable yet significant effects on study reproducibility and outcomes. In addition, we explore how recent developments in brain slice preparation relate to their use as models of epileptic activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas In Vitro / Encéfalo / Epilepsia / Ondas Encefálicas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Epilepsia Ano de publicação: 2017 Tipo de documento: Article País de afiliação: África do Sul
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas In Vitro / Encéfalo / Epilepsia / Ondas Encefálicas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Epilepsia Ano de publicação: 2017 Tipo de documento: Article País de afiliação: África do Sul