Allergic contact dermatitis caused by calcipotriol.
Contact Dermatitis
; 78(2): 139-142, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29114901
ABSTRACT
BACKGROUND:
Calcipotriol, a synthetic vitamin D analogue, is widely used for the topical treatment of psoriasis. It often causes irritant reactions, whereas allergic contact dermatitis has less commonly been reported.OBJECTIVES:
To report on 6 patients (among them an 11-year-old child) who presented with eczematous lesions complicating pre-existing dermatitis, observed in our tertiary referral patch test clinic between 2004 and 2016.METHODS:
Patch tests were performed with the commercial preparation used by the patients and/or its ingredients, including calcipotriol (2 or 10 µg/ml in isopropyl alcohol), according to ESCD patch test guidelines.RESULTS:
Allergic contact dermatitis was confirmed in all cases, and the lesions improved following treatment with topical corticosteroids and/or oral medication.CONCLUSIONS:
When topical treatment with calcipotriol fails to improve, or even worsens, existing skin lesions, contact allergy should be suspected. A patch test concentration of 2 µg/ml in isopropyl alcohol seems to be the most suitable. According to the literature, patients sensitized to calcipotriol may tolerate topical therapy with other vitamin D3 analogues, particularly tacalcitol.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calcitriol
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Dermatite Alérgica de Contato
/
Fármacos Dermatológicos
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Adult
/
Child
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Contact Dermatitis
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Bélgica