Resistance Is Futile: Targeting Mitochondrial Energetics and Metabolism to Overcome Drug Resistance in Cancer Treatment.

Bosc, Claudie; Selak, Mary A; Sarry, Jean-Emmanuel

Bosc, Claudie; Selak, Mary A; Sarry, Jean-Emmanuel.

Afiliação

Bosc C; Inserm, Cancer Research Center of Toulouse, U1037, 31024 Toulouse, France; Université de Toulouse, 31300 Toulouse, France.
Selak MA; Inserm, Cancer Research Center of Toulouse, U1037, 31024 Toulouse, France; Université de Toulouse, 31300 Toulouse, France.
Sarry JE; Inserm, Cancer Research Center of Toulouse, U1037, 31024 Toulouse, France; Université de Toulouse, 31300 Toulouse, France. Electronic address: jean-emmanuel.sarry@inserm.fr.

Cell Metab ; 26(5): 705-707, 2017 Nov 07.

Article em En | MEDLINE | ID: mdl-29117545

ABSTRACT

ABSTRACT

Metabolism is a key regulator of cancer biology; however, its role in therapeutic resistance has remained largely unresolved. Several new studies disclose that mitochondrial metabolism and oxidative phosphorylation at least in part drive chemoresistance in cancer and thus have important implications for targeted and more effective chemotherapies.

Assuntos

Antineoplásicos/farmacologia; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Neoplasias/tratamento farmacológico; Fosforilação Oxidativa/efeitos dos fármacos; Animais; Antineoplásicos/uso terapêutico; Humanos; Camundongos; Mitocôndrias/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação Oxidativa / Resistencia a Medicamentos Antineoplásicos / Mitocôndrias / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França

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