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Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin.
Gu, Helen; Dutreix, Catherine; Rebello, Sam; Ouatas, Taoufik; Wang, Lai; Chun, Dung Yu; Einolf, Heidi J; He, Handan.
Afiliação
  • Gu H; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.G., S.R., L.W., D.Y.C., H.J.E., H.H.); Novartis Pharmaceuticals Corporation, Basel, Switzerland (C.D., T.O.); and Insmed Inc., Bridgewater, New Jersey (D.Y.C.) helen.gu@novartis.com.
  • Dutreix C; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.G., S.R., L.W., D.Y.C., H.J.E., H.H.); Novartis Pharmaceuticals Corporation, Basel, Switzerland (C.D., T.O.); and Insmed Inc., Bridgewater, New Jersey (D.Y.C.).
  • Rebello S; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.G., S.R., L.W., D.Y.C., H.J.E., H.H.); Novartis Pharmaceuticals Corporation, Basel, Switzerland (C.D., T.O.); and Insmed Inc., Bridgewater, New Jersey (D.Y.C.).
  • Ouatas T; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.G., S.R., L.W., D.Y.C., H.J.E., H.H.); Novartis Pharmaceuticals Corporation, Basel, Switzerland (C.D., T.O.); and Insmed Inc., Bridgewater, New Jersey (D.Y.C.).
  • Wang L; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.G., S.R., L.W., D.Y.C., H.J.E., H.H.); Novartis Pharmaceuticals Corporation, Basel, Switzerland (C.D., T.O.); and Insmed Inc., Bridgewater, New Jersey (D.Y.C.).
  • Chun DY; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.G., S.R., L.W., D.Y.C., H.J.E., H.H.); Novartis Pharmaceuticals Corporation, Basel, Switzerland (C.D., T.O.); and Insmed Inc., Bridgewater, New Jersey (D.Y.C.).
  • Einolf HJ; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.G., S.R., L.W., D.Y.C., H.J.E., H.H.); Novartis Pharmaceuticals Corporation, Basel, Switzerland (C.D., T.O.); and Insmed Inc., Bridgewater, New Jersey (D.Y.C.).
  • He H; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.G., S.R., L.W., D.Y.C., H.J.E., H.H.); Novartis Pharmaceuticals Corporation, Basel, Switzerland (C.D., T.O.); and Insmed Inc., Bridgewater, New Jersey (D.Y.C.).
Drug Metab Dispos ; 46(2): 109-121, 2018 02.
Article em En | MEDLINE | ID: mdl-29117990
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estaurosporina / Interações Medicamentosas / Citocromo P-450 CYP3A Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estaurosporina / Interações Medicamentosas / Citocromo P-450 CYP3A Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article