Histone Marks in the 'Driver's Seat': Functional Roles in Steering the Transcription Cycle.
Trends Biochem Sci
; 42(12): 977-989, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-29122461
ABSTRACT
Particular chromatin modifications are associated with different states of gene transcription, yet our understanding of which modifications are causal 'drivers' in promoting transcription is incomplete. Here, we discuss new developments describing the ordered, mechanistic role of select histone marks occurring during distinct steps in the RNA polymerase II (Pol II) transcription cycle. In particular, we highlight the interplay between histone marks in specifying the 'next step' of transcription. While many studies have described correlative relationships between histone marks and their occupancy at distinct gene regions, we focus on studies that elucidate clear functional consequences of specific histone marks during different stages of transcription. These recent discoveries have refined our current mechanistic understanding of how histone marks promote Pol II transcriptional progression.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
RNA Polimerase II
/
Código das Histonas
Limite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos