Exercise improves recognition memory and synaptic plasticity in the prefrontal cortex for rats modelling vascular dementia.
Neurol Res
; 40(1): 68-77, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29126372
ABSTRACT
OBJECTIVES:
Functional electrical stimulation (FES) may induce involuntary exercise and make beneficial effects on vascular dementia (VD) by strengthening the BDNF-pCREB-mediated pathway and hippocampal plasticity. Whether FES improves recognition memory and synaptic plasticity in the prefrontal cortex (PFC) was investigated by establishing a VD model.METHODS:
The VD rats were administered with two weeks of voluntary exercise, forced exercise, or involuntary exercise induced with FES. Sham-operated and control groups were also included. The behavioral changes were assessed with the novel object recognition test and novel object location test. The expression levels of key proteins related to synaptic plasticity in the PFC were also detected.RESULTS:
All types of exercise improved the rats' novel object recognition index, but only voluntary exercise and involuntary exercise induced with FES improved the novel object location index. Any sort of exercise enhanced the expression of key proteins in the PFC.CONCLUSION:
Involuntary exercise induced with FES can improve recognition memory in VD better than forced exercise. The mechanism is associated with increased synaptic plasticity in the PFC. FES may be a useful alternative tool for cognitive rehabilitation.Palavras-chave
AMPA: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF: brain-derived neurotrophic factor; BSA: bovine serum albumin; CREB: AMP-response element binding protein; CaMKII: calcium/calmodulin dependent protein kinase II; EGF: epidermal growth factor; FES: functional electrical stimulation; FGF: fibroblast growth factor; GluR1: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor 1; LTP: long-term potentiation; MAP-2: microtubule-associated protein 2; NMDA: N-methyl-D-aspartic acid; NOLT: novel object location test; NORT: novel object recognition test; NR1: N-methyl-D-aspartic acid receptor 1; PFC: prefrontal cortex; PSD-95: postsynaptic density 95; SYN: synapsin I; SYP: synaptophysin; VD: vascular dementia; Vascular dementia; exercise; functional electrical stimulation; recognition memory; synaptic plasticity
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
/
Demência Vascular
/
Córtex Pré-Frontal
/
Reconhecimento Psicológico
/
Transtornos da Memória
/
Plasticidade Neuronal
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neurol Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China