High flow or titrated oxygen for obese medical inpatients: a randomised crossover trial.
Med J Aust
; 207(10): 430-434, 2017 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-29129174
ABSTRACT
OBJECTIVE:
To compare the effects on transcutaneous carbon dioxide tension (Ptco2) of high concentration and titrated oxygen therapy in medical inpatients with morbid obesity who were not selected for a pre-existing diagnosis of obesity hypoventilation syndrome.DESIGN:
A randomised, crossover trial undertaken between February and September 2015.SETTING:
Internal medicine service, Wellington Regional Hospital, New Zealand.PARTICIPANTS:
22 adult inpatients, aged 16 years or more, with a body mass index exceeding 40 kg/m2.INTERVENTIONS:
Participants received in random order two 60-minute interventions, with a minimum 30-minute washout period between treatments titrated oxygen therapy (oxygen delivered, if required, via nasal prongs to achieve peripheral oxygen saturation [Spo2] of 88-92%), and high concentration oxygen therapy (delivered via Hudson mask at 8 L/min, without regard to Spo2). Ptco2 and Spo2 were recorded at 10-minute intervals. MAIN OUTCOMEMEASURE:
Ptco2 at 60 minutes, adjusted for baseline.RESULTS:
Baseline Ptco2 was 45 mmHg or lower for 16 participants with full data (73%). The mean difference in Ptco2 between high concentration and titrated oxygen therapy at 60 minutes was 3.2 mmHg (95% CI, 1.3-5.2 mmHg; P = 0.002).CONCLUSION:
High concentration oxygen therapy increases Ptco2 in morbidly obese patients. Our findings support guidelines that advocate oxygen therapy, if required in patients with morbid obesity, be titrated to achieve a target Spo2 of 88-92%. CLINICAL TRIAL REGISTRATION Australian New Zealand Clinical Trials Registry, ACTRN12610000522011.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigenoterapia
/
Obesidade Mórbida
/
Hipóxia
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Guideline
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Med J Aust
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Nova Zelândia