Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors.

Wang, Bao-Lei; Zhang, Li-Yuan; Liu, Xing-Hai; Ma, Yi; Zhang, Yan; Li, Zheng-Ming; Zhang, Xiao

Wang, Bao-Lei; Zhang, Li-Yuan; Liu, Xing-Hai; Ma, Yi; Zhang, Yan; Li, Zheng-Ming; Zhang, Xiao.

Afiliação

Wang BL; State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Enginnering(Tianjin), College of Chemistry, Nankai University, Tianjian 300071, PR China. Electronic address: nkwbl@nankai.edu.cn.
Zhang LY; State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Enginnering(Tianjin), College of Chemistry, Nankai University, Tianjian 300071, PR China.
Liu XH; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, PR China.
Ma Y; State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Enginnering(Tianjin), College of Chemistry, Nankai University, Tianjian 300071, PR China.
Zhang Y; State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Enginnering(Tianjin), College of Chemistry, Nankai University, Tianjian 300071, PR China.
Li ZM; State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Enginnering(Tianjin), College of Chemistry, Nankai University, Tianjian 300071, PR China. Electronic address: nkzml@vip.163.com.
Zhang X; State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Enginnering(Tianjin), College of Chemistry, Nankai University, Tianjian 300071, PR China.

Bioorg Med Chem Lett ; 27(24): 5457-5462, 2017 12 15.

Article em En | MEDLINE | ID: mdl-29132751

Assuntos

Antifúngicos/síntese química; Herbicidas/síntese química; Cetol-Ácido Redutoisomerase/antagonistas & inibidores; Bases de Mannich/química; Triazóis/química; Antifúngicos/química; Antifúngicos/farmacologia; Sítios de Ligação; Echinochloa/efeitos dos fármacos; Echinochloa/enzimologia; Fungos/efeitos dos fármacos; Fungos/enzimologia; Herbicidas/química; Herbicidas/farmacologia; Cetol-Ácido Redutoisomerase/metabolismo; Cinética; Simulação de Acoplamento Molecular; Estrutura Terciária de Proteína; Relação Quantitativa Estrutura-Atividade

Palavras-chave

1,2,4-Triazole thione; Fungicidal activity; Ketol-acid reductoisomerase inhibitors; Mannich base; Structure-activity relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Cetol-Ácido Redutoisomerase / Herbicidas / Bases de Mannich / Antifúngicos Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article

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