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A combination intervention strategy to improve linkage to and retention in HIV care following diagnosis in Mozambique: A cluster-randomized study.
Elul, Batya; Lamb, Matthew R; Lahuerta, Maria; Abacassamo, Fatima; Ahoua, Laurence; Kujawski, Stephanie A; Tomo, Maria; Jani, Ilesh.
Afiliação
  • Elul B; ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
  • Lamb MR; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
  • Lahuerta M; ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
  • Abacassamo F; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
  • Ahoua L; ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
  • Kujawski SA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
  • Tomo M; Center for Collaboration in Health, Maputo, Mozambique.
  • Jani I; ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
PLoS Med ; 14(11): e1002433, 2017 Nov.
Article em En | MEDLINE | ID: mdl-29136001
ABSTRACT

BACKGROUND:

Concerning gaps in the HIV care continuum compromise individual and population health. We evaluated a combination intervention strategy (CIS) targeting prevalent barriers to timely linkage and sustained retention in HIV care in Mozambique. METHODS AND

FINDINGS:

In this cluster-randomized trial, 10 primary health facilities in the city of Maputo and Inhambane Province were randomly assigned to provide the CIS or the standard of care (SOC). The CIS included point-of-care CD4 testing at the time of diagnosis, accelerated ART initiation, and short message service (SMS) health messages and appointment reminders. A pre-post intervention 2-sample design was nested within the CIS arm to assess the effectiveness of CIS+, an enhanced version of the CIS that additionally included conditional non-cash financial incentives for linkage and retention. The primary outcome was a combined outcome of linkage to care within 1 month and retention at 12 months after diagnosis. From April 22, 2013, to June 30, 2015, we enrolled 2,004 out of 5,327 adults ≥18 years of age diagnosed with HIV in the voluntary counseling and testing clinics of participating health facilities 744 (37%) in the CIS group, 493 (25%) in the CIS+ group, and 767 (38%) in the SOC group. Fifty-seven percent of the CIS group achieved the primary outcome versus 35% in the SOC group (relative risk [RR]CIS vs SOC = 1.58, 95% CI 1.05-2.39). Eighty-nine percent of the CIS group linked to care on the day of diagnosis versus 16% of the SOC group (RRCIS vs SOC = 9.13, 95% CI 1.65-50.40). There was no significant benefit of adding financial incentives to the CIS in terms of the combined outcome (55% of the CIS+ group achieved the primary outcome, RRCIS+ vs CIS = 0.96, 95% CI 0.81-1.16). Key limitations include the use of existing medical records to assess outcomes, the inability to isolate the effect of each component of the CIS, non-concurrent enrollment of the CIS+ group, and exclusion of many patients newly diagnosed with HIV.

CONCLUSIONS:

The CIS showed promise for making much needed gains in the HIV care continuum in our study, particularly in the critical first step of timely linkage to care following diagnosis. TRIAL REGISTRATION ClinicalTrials.gov NCT01930084.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Cooperação do Paciente / Sistemas Automatizados de Assistência Junto ao Leito / Fármacos Anti-HIV / Intervenção Médica Precoce Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: PLoS Med Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Cooperação do Paciente / Sistemas Automatizados de Assistência Junto ao Leito / Fármacos Anti-HIV / Intervenção Médica Precoce Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: PLoS Med Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos