Role of protein dynamics in transmembrane receptor signalling.
Curr Opin Struct Biol
; 48: 74-82, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29136528
ABSTRACT
Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Receptores de Citocinas
/
Receptores Proteína Tirosina Quinases
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Receptores Acoplados a Proteínas G
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Canais Iônicos de Abertura Ativada por Ligante
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Struct Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Dinamarca