Challenges to laser-assisted drug delivery: Applying theory to clinical practice.
Lasers Surg Med
; 50(1): 20-27, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29154501
ABSTRACT
BACKGROUND:
The percutaneous penetration of topically applied compounds can be enhanced using external chemical or physical sources and thus laser-assisted drug delivery is a burgeoning area of interest within the field of dermatology.OBJECTIVES:
This article briefly discusses the mechanism of laser-assisted drug delivery and expands upon the challenges and safety issues that may arise in the clinical implementation of this modality.RESULTS:
The existing literature demonstrates that investigators and clinicians in dermatology have successfully delivered anti-inflammatory, anti-neoplastic, and anti-oxidative medications transdermally for the treatment of a variety of conditions including scarring, photoageing, and cutaneous neoplasia. Despite growth of the field, much remains to be learned about the applicability of laser-assisted drug delivery in humans, and practitioners are faced with new safety concerns that may be associated with this treatment modality.CONCLUSIONS:
Challenges in laser assisted drug delivery include unpredictability of dosing and response to therapy, possibility of inducing local and systemic reactions, and variability in treatment regimens. Lasers Surg. Med. 5020-27, 2018. © 2017 Wiley Periodicals, Inc.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Administração Cutânea
/
Sistemas de Liberação de Medicamentos
/
Lasers de Gás
/
Lasers de Estado Sólido
Limite:
Humans
Idioma:
En
Revista:
Lasers Surg Med
Ano de publicação:
2018
Tipo de documento:
Article