Biophysical and Sequence-Based Methods for Identifying Monovalent and Bivalent Antibodies with High Colloidal Stability.

Alam, Magfur E; Geng, Steven B; Bender, Christian; Ludwig, Seth D; Linden, Lars; Hoet, Rene; Tessier, Peter M

Alam, Magfur E; Geng, Steven B; Bender, Christian; Ludwig, Seth D; Linden, Lars; Hoet, Rene; Tessier, Peter M.

Afiliação

Alam ME; Isermann Department of Chemical & Biological Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, New York 12180, United States.
Geng SB; Isermann Department of Chemical & Biological Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, New York 12180, United States.
Bender C; Pharmaceuticals, Bayer AG , Nattermannallee 1, Cologne 50829, Germany.
Ludwig SD; Isermann Department of Chemical & Biological Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, New York 12180, United States.
Linden L; Pharmaceuticals, Bayer AG , Aprather Weg 18A, Wuppertal 42117, Germany.
Hoet R; Pharmaceuticals, Bayer AG , Nattermannallee 1, Cologne 50829, Germany.
Tessier PM; Isermann Department of Chemical & Biological Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, New York 12180, United States.

Mol Pharm ; 15(1): 150-163, 2018 01 02.

Article em En | MEDLINE | ID: mdl-29154550

Assuntos

Anticorpos Monoclonais/química; Coloides/química; Cromatografia em Gel; Ouro/química; Humanos; Nanopartículas Metálicas/química; Solubilidade; Viscosidade

Palavras-chave

AC-SINS; developability; formulation; mAb; solubility; viscosity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coloides / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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