Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease.

Hao, Liuyi; Sun, Qian; Zhong, Wei; Zhang, Wenliang; Sun, Xinguo; Zhou, Zhanxiang

Hao, Liuyi; Sun, Qian; Zhong, Wei; Zhang, Wenliang; Sun, Xinguo; Zhou, Zhanxiang.

Afiliação

Hao L; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA.
Sun Q; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA.
Zhong W; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA.
Zhang W; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA.
Sun X; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA.
Zhou Z; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA; Department of Nutrition, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA. Electronic address: z_z

Redox Biol ; 14: 626-636, 2018 04.

Article em En | MEDLINE | ID: mdl-29156373

Assuntos

Acetaldeído/metabolismo; Aldeído-Desidrogenase Mitocondrial/metabolismo; Hepatopatias Alcoólicas/prevenção & controle; Estresse Nitrosativo/efeitos dos fármacos; Compostos Organofosforados/uso terapêutico; Estresse Oxidativo/efeitos dos fármacos; Substâncias Protetoras/uso terapêutico; Ubiquinona/análogos & derivados; Animais; Linhagem Celular; Hepatopatias Alcoólicas/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Processamento de Proteína Pós-Traducional/efeitos dos fármacos; Ubiquinona/uso terapêutico

Palavras-chave

Alcoholic liver disease; Aldehyde dehydrogenase 2; MitoQ; Posttranslational modification

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organofosforados / Ubiquinona / Estresse Oxidativo / Substâncias Protetoras / Aldeído-Desidrogenase Mitocondrial / Estresse Nitrosativo / Hepatopatias Alcoólicas / Acetaldeído Limite: Animals Idioma: En Revista: Redox Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google