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Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud.
Cho, Namki; Du, Yongle; Valenciano, Ana Lisa; Fernández-Murga, Maria L; Goetz, Michael; Clement, Jason; Cassera, Maria B; Kingston, David G I.
Afiliação
  • Cho N; Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, United States.
  • Du Y; Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, United States.
  • Valenciano AL; Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA 30602, United States.
  • Fernández-Murga ML; Department of Biochemistry, M/C 0308, Virginia Tech, Blacksburg, VA 24061, United States.
  • Goetz M; Natural Products Discovery Institute, 3805 Old Easton Road, Doylestown, PA 18902, United States.
  • Clement J; Natural Products Discovery Institute, 3805 Old Easton Road, Doylestown, PA 18902, United States.
  • Cassera MB; Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA 30602, United States.
  • Kingston DGI; Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, United States. Electronic address: dkingston@vt.edu.
Bioorg Med Chem Lett ; 28(1): 40-42, 2018 01 01.
Article em En | MEDLINE | ID: mdl-29162457
ABSTRACT
A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud. bulbs resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan (1), along with the 3 known crinane alkaloids 2-4 and the two lycorane alkaloids 5-6. The structures were elucidated by interpretation of combined HR-ESIMS, CD and 2D NMR spectroscopic data. Among these isolated compounds the lycorane-type alkaloid acetylcaranine (5) exhibited strong antiplasmodial activity, while compounds 3 and 4 were moderately active, and compounds 1 and 6 were inactive.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides de Amaryllidaceae / Alcaloides / Asparagales / Antimaláricos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides de Amaryllidaceae / Alcaloides / Asparagales / Antimaláricos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos