Cancer history: A predictor of IPMN subtype and dysplastic status?
Am J Surg
; 215(3): 522-525, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-29174163
ABSTRACT
INTRODUCTION:
The aim of this study was to determine the association of PMH and FH of pancreatic (PDAC) and non-pancreatic cancers with IPMN malignant risk.METHODS:
A retrospective review of a prospective database of IPMN patients undergoing resection was performed to assess FH and PMH.RESULTS:
FH of PDAC was present in 13% of 362 included patients. Of these, 8% had at least one first degree relative (FDR) with PDAC. The rate of PDAC positive FH in non-invasive versus invasive IPMN patients was 14% and 8%, respectively (p = 0.3). In main duct IPMN patients, FH (44%) and PMH of non-pancreatic cancer (16%) was higher than that seen in branch duct IPMN (FH 29%; PMH 6%; p = 0.004 and 0.008).CONCLUSIONS:
FH of PDAC is not associated with IPMN malignant progression. FH and PMH of non-pancreatic cancer is associated with main duct IPMN, the subtype with the highest rate of invasive transformation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
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Carcinoma Ductal Pancreático
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Neoplasias Intraductais Pancreáticas
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Anamnese
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Am J Surg
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos