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Genome sequence and analysis of Escherichia coli production strain LS5218.
Rand, Jacqueline M; Gordon, Gina C; Mehrer, Christopher R; Pfleger, Brian F.
Afiliação
  • Rand JM; Department of Chemical and Biological Engineering, University of Wisconsin, Madison, United States.
  • Gordon GC; Department of Chemical and Biological Engineering, University of Wisconsin, Madison, United States.
  • Mehrer CR; Microbiology Doctoral Training Program, University of Wisconsin, Madison, United States.
  • Pfleger BF; Department of Chemical and Biological Engineering, University of Wisconsin, Madison, United States.
Metab Eng Commun ; 5: 78-83, 2017 Dec.
Article em En | MEDLINE | ID: mdl-29188187
Escherichia coli strain LS5218 is a useful host for the production of fatty acid derived products, but the genetics underlying this utility have not been fully investigated. Here, we report the genome sequence of LS5218 and a list of large mutations and single nucleotide permutations (SNPs) relative to E. coli K-12 strain MG1655. We discuss how genetic differences may affect the physiological differences between LS5218 and MG1655. We find that LS5218 is more closely related to E. coli strain NCM3722 and suspect that small genetic differences between K-12 derived strains may have a significant impact on metabolic engineering efforts.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Metab Eng Commun Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Metab Eng Commun Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos