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Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate.
Clark, Robert L; Edwards, Tammye L; Longo, Monica; Kinney, Joseph; Walker, Don K; Rhodes, Jon; Clode, Sally A; Rückle, Thomas; Wells, Timothy; Andenmatten, Nicole; Huber, Anna Christine.
Afiliação
  • Clark RL; Artemis Pharmaceutical Research, Jacksonville, Florida.
  • Edwards TL; Charles River Laboratories, Ashland, Ohio.
  • Longo M; Accelera S.r.l, Nerviano, Italy.
  • Kinney J; Pharmaron UK, Northamptonshire, United Kingdom.
  • Walker DK; Broadstairs, United Kingdom.
  • Rhodes J; Covance Laboratories Ltd, Reproduction Toxicology, Harrogate, North Yorkshire, United Kingdom.
  • Clode SA; Covance Laboratories Ltd, Reproduction Toxicology, Harrogate, North Yorkshire, United Kingdom.
  • Rückle T; Medicines for Malaria Venture, Geneva, Switzerland.
  • Wells T; Medicines for Malaria Venture, Geneva, Switzerland.
  • Andenmatten N; Medicines for Malaria Venture, Geneva, Switzerland.
  • Huber AC; Huber ToxPath Consulting, Ambler, Pennsylvania.
Birth Defects Res ; 110(7): 553-578, 2018 04 17.
Article em En | MEDLINE | ID: mdl-29193867
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peróxidos / Adamantano / Embrião de Mamíferos / Artesunato / Antimaláricos Limite: Animals Idioma: En Revista: Birth Defects Res Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peróxidos / Adamantano / Embrião de Mamíferos / Artesunato / Antimaláricos Limite: Animals Idioma: En Revista: Birth Defects Res Ano de publicação: 2018 Tipo de documento: Article