Mechanistic insights into the role of glycosaminoglycans in delivery of polymeric nucleic acid nanoparticles by molecular dynamics simulations.

Meneksedag-Erol, Deniz; Tang, Tian; Uludag, Hasan

Meneksedag-Erol, Deniz; Tang, Tian; Uludag, Hasan.

Afiliação

Meneksedag-Erol D; Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada; Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada. Electronic address: meneksed@ualberta.ca.
Tang T; Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada; Department of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada. Electronic address: tian.tang@ualberta.ca.
Uludag H; Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada; Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada. Electronic address: hasan.uludag@ualberta.ca.

Biomaterials ; 156: 107-120, 2018 02.

Article em En | MEDLINE | ID: mdl-29195180

Assuntos

Glicosaminoglicanos/química; Simulação de Dinâmica Molecular; Nanopartículas/química; Ácidos Nucleicos/química; Polímeros/química; Heparina/química; Conformação Molecular; Polietilenoimina/química; RNA Interferente Pequeno

Palavras-chave

Glycosaminoglycan; Heparin; Molecular dynamics; Polyethylenimine; Polymeric nanoparticle; Polynucleotide delivery; siRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Ácidos Nucleicos / Nanopartículas / Simulação de Dinâmica Molecular / Glicosaminoglicanos Idioma: En Revista: Biomaterials Ano de publicação: 2018 Tipo de documento: Article

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