In vitro leishmanicidal and trypanocidal evaluation and magnetic properties of 7-amino-1,2,4-triazolo[1,5-a]pyrimidine Cu(II) complexes.
J Inorg Biochem
; 180: 26-32, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29227923
ABSTRACT
Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (7atp) and Cu (II) salts. Crystal structures of [Cu2(µ-7atp)4Cl2]Cl2·4H2O (1) and [Cu2(µ-7atp)4(H2O)2](NO3)4·H2O (2) have been studied by X-ray diffraction methods and characterized by spectroscopic and thermal analysis. Magnetic studies of these dinuclear complexes have revealed the existence of moderate antiferromagnetic interactions between the copper ions, with J values of -91.2 and -96.1cm-1 respectively. It must be highlighted that the antiparasitic activity of these new complexes has been studied in vitro against three different strains of leishmania spp. and Trypanosoma cruzi, showing a higher efficacy than the 7atp ligand and the reference commercial drugs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Triazóis
/
Tripanossomicidas
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Trypanosoma cruzi
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Cobre
/
Complexos de Coordenação
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Leishmania
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Magnetismo
Limite:
Animals
Idioma:
En
Revista:
J Inorg Biochem
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha