Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria.
ACS Infect Dis
; 4(2): 118-122, 2018 02 09.
Article
em En
| MEDLINE
| ID: mdl-29236466
ABSTRACT
The oral microbiome is a complex ecological niche where both commensal and pathogenic bacteria coexist. Previous reports have cited that the plant isolate honokiol is a potent inhibitor of S. mutans biofilms. Herein we report a cross-coupling method that provides access to a concise library of honokiol-inspired analogs. Through this work we determined that the inhibitory activity of honokiol is highly dependent on the growth conditions. Further, we identify a series of analogs that display significant potency against oral bacteria leading to the discovery of a potent antimicrobial.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estomatite
/
Bactérias
/
Infecções Bacterianas
/
Compostos de Bifenilo
/
Lignanas
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
ACS Infect Dis
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos