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Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.
Faller, Kiterie M E; Atzler, Dorothee; McAndrew, Debra J; Zervou, Sevasti; Whittington, Hannah J; Simon, Jillian N; Aksentijevic, Dunja; Ten Hove, Michiel; Choe, Chi-Un; Isbrandt, Dirk; Casadei, Barbara; Schneider, Jurgen E; Neubauer, Stefan; Lygate, Craig A.
Afiliação
  • Faller KME; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Atzler D; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  • McAndrew DJ; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Institute for Cardiovascular Prevention (IPEK), Pettenkoferstraße 8a & 9, 80336 Munich, Germany.
  • Zervou S; Walther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University, Goethestrasse 33, 80336 Munich, Germany.
  • Whittington HJ; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Simon JN; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Aksentijevic D; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Ten Hove M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Choe CU; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Isbrandt D; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Casadei B; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
  • Schneider JE; Experimental Neurophysiology, German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
  • Neubauer S; The Institute for Molecular and Behavioral Neuroscience, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
  • Lygate CA; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
Cardiovasc Res ; 114(3): 417-430, 2018 Mar 01.
Article em En | MEDLINE | ID: mdl-29236952

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Função Ventricular Esquerda / Disfunção Ventricular Esquerda / Creatina / Amidinotransferases / Homoarginina / Contração Miocárdica / Miocárdio Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Cardiovasc Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Função Ventricular Esquerda / Disfunção Ventricular Esquerda / Creatina / Amidinotransferases / Homoarginina / Contração Miocárdica / Miocárdio Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Cardiovasc Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido