Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors.
Biomark Med
; 12(1): 35-44, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29243509
ABSTRACT
AIM:
The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown.METHODS:
Immunohistochemical expression of MTAP was accessed in 112 patients with ESFT in a tissue microarray platform and associated with clinicopathological parameters and overall survival (OS).RESULTS:
Loss of MTAP expression was significantly associated with lower OS in both univariate and multivariate analyses.CONCLUSION:
Loss of MTAP expression is an independent negative prognostic biomarker in ESFT.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma de Ewing
/
Biomarcadores Tumorais
/
Purina-Núcleosídeo Fosforilase
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biomark Med
Assunto da revista:
BIOQUIMICA
/
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Brasil