Generic wound signals initiate regeneration in missing-tissue contexts.
Nat Commun
; 8(1): 2282, 2017 12 22.
Article
em En
| MEDLINE
| ID: mdl-29273738
ABSTRACT
Despite the identification of numerous regulators of regeneration in different animal models, a fundamental question remains why do some wounds trigger the full regeneration of lost body parts, whereas others resolve by mere healing? By selectively inhibiting regeneration initiation, but not the formation of a wound epidermis, here we create headless planarians and finless zebrafish. Strikingly, in both missing-tissue contexts, injuries that normally do not trigger regeneration activate complete restoration of heads and fin rays. Our results demonstrate that generic wound signals have regeneration-inducing power. However, they are interpreted as regeneration triggers only in a permissive tissue context when body parts are missing, or when tissue-resident polarity signals, such as Wnt activity in planarians, are modified. Hence, the ability to decode generic wound-induced signals as regeneration-initiating cues may be the crucial difference that distinguishes animals that regenerate from those that cannot.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Planárias
/
Regeneração
/
Cicatrização
/
Peixe-Zebra
/
Sistema de Sinalização das MAP Quinases
/
Via de Sinalização Wnt
Limite:
Animals
Idioma:
En
Revista:
Nat Commun
Assunto da revista:
BIOLOGIA
/
CIENCIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha