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Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Demenais, Florence; Margaritte-Jeannin, Patricia; Barnes, Kathleen C; Cookson, William O C; Altmüller, Janine; Ang, Wei; Barr, R Graham; Beaty, Terri H; Becker, Allan B; Beilby, John; Bisgaard, Hans; Bjornsdottir, Unnur Steina; Bleecker, Eugene; Bønnelykke, Klaus; Boomsma, Dorret I; Bouzigon, Emmanuelle; Brightling, Christopher E; Brossard, Myriam; Brusselle, Guy G; Burchard, Esteban; Burkart, Kristin M; Bush, Andrew; Chan-Yeung, Moira; Chung, Kian Fan; Couto Alves, Alexessander; Curtin, John A; Custovic, Adnan; Daley, Denise; de Jongste, Johan C; Del-Rio-Navarro, Blanca E; Donohue, Kathleen M; Duijts, Liesbeth; Eng, Celeste; Eriksson, Johan G; Farrall, Martin; Fedorova, Yuliya; Feenstra, Bjarke; Ferreira, Manuel A; Freidin, Maxim B; Gajdos, Zofia; Gauderman, Jim; Gehring, Ulrike; Geller, Frank; Genuneit, Jon; Gharib, Sina A; Gilliland, Frank; Granell, Raquel; Graves, Penelope E; Gudbjartsson, Daniel F; Haahtela, Tari.
Afiliação
  • Demenais F; Genetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France. florence.demenais@inserm.fr.
  • Margaritte-Jeannin P; Institut Universitaire d'Hématologie, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France. florence.demenais@inserm.fr.
  • Barnes KC; Genetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
  • Cookson WOC; Institut Universitaire d'Hématologie, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France.
  • Altmüller J; Division of Biomedical Informatics and Personalized Medicine, Colorado Center for Personalized Medicine, University of Colorado, Denver, CO, USA.
  • Ang W; Section of Genomic Medicine, National Heart and Lung Institute, London, UK.
  • Barr RG; Cologne Center for Genomics and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
  • Beaty TH; School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
  • Becker AB; Departments of Medicine and Epidemiology, Columbia University, New York, NY, USA.
  • Beilby J; Division of Genetic Epidemiology, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  • Bisgaard H; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Bjornsdottir US; Department of the Diagnostic Genomics Laboratory, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.
  • Bleecker E; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Bønnelykke K; Department of Medicine, Landspitali, National University Hospital of Iceland, Reykjavik, Iceland.
  • Boomsma DI; Center for Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • Bouzigon E; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Brightling CE; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrjie Universiteit, Amsterdam, The Netherlands.
  • Brossard M; Genetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
  • Brusselle GG; Institut Universitaire d'Hématologie, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France.
  • Burchard E; University of Leicester, Institute for Lung Health, Glenfield Hospital, Leicester, UK.
  • Burkart KM; Genetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
  • Bush A; Institut Universitaire d'Hématologie, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France.
  • Chan-Yeung M; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
  • Chung KF; Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Couto Alves A; Department of Respiratory Medicine, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Curtin JA; Department of Bioengineering & Therapeutic Sciences and Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Custovic A; Division of Pulmonary, Allergy and Critical Care, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
  • Daley D; National Heart and Lung Institute, Imperial College London, London, UK.
  • de Jongste JC; Royal Brompton Harefield National Health Service (NHS) Foundation Trust, London, UK.
  • Del-Rio-Navarro BE; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Donohue KM; National Heart and Lung Institute, Imperial College London, London, UK.
  • Duijts L; Biomedical Research Unit, Royal Brompton & Harefield National Health Service (NHS) Trust, London, UK.
  • Eng C; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Eriksson JG; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
  • Farrall M; Department of Paediatrics, Imperial College London, London, UK.
  • Fedorova Y; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Feenstra B; Centre for Heart and Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
  • Ferreira MA; Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Freidin MB; Departments of Medicine and Epidemiology, Columbia University, New York, NY, USA.
  • Gajdos Z; Department of Pediatrics, Division of Respiratory Medicine, and Department of Pediatrics, Division of Neonatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Gauderman J; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Gehring U; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Geller F; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Genuneit J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Gharib SA; Institute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russian Federation.
  • Gilliland F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Granell R; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Gudbjartsson DF; Population Genetics Laboratory, Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russian Federation.
  • Haahtela T; Divisions of Genetics and Endocrinology, Children's Hospital, Boston, MA, USA.
Nat Genet ; 50(1): 42-53, 2018 01.
Article em En | MEDLINE | ID: mdl-29273806
ABSTRACT
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Elementos Facilitadores Genéticos Tipo de estudo: Etiology_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Elementos Facilitadores Genéticos Tipo de estudo: Etiology_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França