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18F-Trifluoromethylation of Unmodified Peptides with 5-18F-(Trifluoromethyl)dibenzothiophenium Trifluoromethanesulfonate.
Verhoog, Stefan; Kee, Choon Wee; Wang, Yanlan; Khotavivattana, Tanatorn; Wilson, Thomas C; Kersemans, Veerle; Smart, Sean; Tredwell, Matthew; Davis, Benjamin G; Gouverneur, Véronique.
Afiliação
  • Verhoog S; Chemistry Research Laboratory, University of Oxford , 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Kee CW; Chemistry Research Laboratory, University of Oxford , 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Wang Y; Chemistry Research Laboratory, University of Oxford , 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Khotavivattana T; Chemistry Research Laboratory, University of Oxford , 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Wilson TC; Chemistry Research Laboratory, University of Oxford , 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Kersemans V; Oxford Institute for Radiation Oncology, University of Oxford , Roosevelt Drive, Oxford OX3 7DQ, United Kingdom.
  • Smart S; Oxford Institute for Radiation Oncology, University of Oxford , Roosevelt Drive, Oxford OX3 7DQ, United Kingdom.
  • Tredwell M; Chemistry Research Laboratory, University of Oxford , 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Davis BG; Chemistry Research Laboratory, University of Oxford , 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Gouverneur V; Chemistry Research Laboratory, University of Oxford , 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
J Am Chem Soc ; 140(5): 1572-1575, 2018 02 07.
Article em En | MEDLINE | ID: mdl-29301394
ABSTRACT
The 18F-labeling of 5-(trifluoromethyl)-dibenzothiophenium trifluoromethanesulfonate, commonly referred to as the Umemoto reagent, has been accomplished applying a halogen exchange 18F-fluorination with 18F-fluoride, followed by oxidative cyclization with Oxone and trifluoromethanesulfonic anhydride. This new 18F-reagent allows for the direct chemoselective 18F-labeling of unmodified peptides at the thiol cysteine residue.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Hidrocarbonetos Fluorados Idioma: En Revista: J Am Chem Soc Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Hidrocarbonetos Fluorados Idioma: En Revista: J Am Chem Soc Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido