Somatic mutations activating Wiskott-Aldrich syndrome protein concomitant with RAS pathway mutations in juvenile myelomonocytic leukemia patients.

Coppe, Alessandro; Nogara, Leonardo; Pizzuto, Matteo Samuele; Cani, Alice; Cesaro, Simone; Masetti, Riccardo; Locatelli, Franco; Te Kronnie, Geertruy; Basso, Giuseppe; Bortoluzzi, Stefania; Bresolin, Silvia

Coppe, Alessandro; Nogara, Leonardo; Pizzuto, Matteo Samuele; Cani, Alice; Cesaro, Simone; Masetti, Riccardo; Locatelli, Franco; Te Kronnie, Geertruy; Basso, Giuseppe; Bortoluzzi, Stefania; Bresolin, Silvia.

Afiliação

Coppe A; Department of Molecular Medicine, University of Padova, Padova, Italy.
Nogara L; Department of Biomedical Sciences, University of Padova, Padova, Italy.
Pizzuto MS; Laboratory of Onco-Hematology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
Cani A; Laboratory of Onco-Hematology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
Cesaro S; Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Masetti R; Oncologia ed Ematologia Pediatrica "Lalla Seràgnoli", University of Bologna, Bologna, Italy.
Locatelli F; Department of Pediatric Onco-Hematology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy.
Te Kronnie G; Laboratory of Onco-Hematology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
Basso G; Laboratory of Onco-Hematology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
Bortoluzzi S; Department of Molecular Medicine, University of Padova, Padova, Italy.
Bresolin S; Laboratory of Onco-Hematology, Department of Women's and Children's Health, University of Padova, Padova, Italy.

Hum Mutat ; 39(4): 579-587, 2018 04.

Article em En | MEDLINE | ID: mdl-29316027

Assuntos

Mutação com Ganho de Função; Leucemia Mielomonocítica Juvenil/genética; Proteína da Síndrome de Wiskott-Aldrich/genética; Proteínas ras/genética; Criança; Humanos; Masculino; Transdução de Sinais/genética

Palavras-chave

JMML; RAS pathway; WASP; sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas ras / Proteína da Síndrome de Wiskott-Aldrich / Leucemia Mielomonocítica Juvenil / Mutação com Ganho de Função Limite: Child / Humans / Male Idioma: En Revista: Hum Mutat Assunto da revista: GENETICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália

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