Sézary syndrome managed with histone deacetylase inhibitor followed by anti-CCR4 monoclonal antibody.
Clin Exp Dermatol
; 43(3): 281-285, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29327377
ABSTRACT
A 70-year-old man presented to our clinic with a 10-year history of recurrent pruritic erythema and plaques on his trunk and limbs. Based on the pathological findings and monoclonal rearrangement of the T-cell receptor (TCR)-Cß1 gene, mycosis fungoides (T2N0M0B0 stage IB) was diagnosed. Despite combination therapy including histone deacetylase inhibitor (vorinostat), the symptoms slowly evolved into Sézary syndrome (SS; T4N1M0B2) over 4 years, with dense infiltrates due to atypical lymphocytes expressing CCR4 developing in the entire dermis. Anti-CCR4 monoclonal antibody (mogamulizumab) treatment was started. After seven courses, the CCR4-positive atypical lymphocytes decreased in the dermis to levels below those seen at the outset of treatment. To our knowledge, there is no previous report of a case of SS managed with vorinostat followed by mogamulizumab demonstrating such a remarkable change in the pathological state following treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Síndrome de Sézary
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Receptores CCR4
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Inibidores de Histona Desacetilases
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Anticorpos Monoclonais Humanizados
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Ácidos Hidroxâmicos
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Antineoplásicos
Limite:
Aged
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Humans
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Male
Idioma:
En
Revista:
Clin Exp Dermatol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão