Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities.
Pharmacol Ther
; 186: 73-87, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29330085
ABSTRACT
Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of death and disability worldwide. As such, new therapies are required to limit myocardial infarct (MI) size, prevent adverse left ventricular (LV) remodeling, and reduce the onset of heart failure following AMI. The inflammatory response to AMI, plays a critical role in determining MI size, and a persistent pro-inflammatory reaction can contribute to adverse post-MI LV remodeling, making inflammation an important therapeutic target for improving outcomes following AMI. In this article, we provide an overview of the multiple players (and their dynamic roles) involved in the complex inflammatory response to AMI and subsequent LV remodeling, and highlight future opportunities for targeting inflammation as a therapeutic strategy for limiting MI size, preventing adverse LV remodeling, and reducing heart failure in AMI patients.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mediadores da Inflamação
/
Remodelação Ventricular
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Insuficiência Cardíaca
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Anti-Inflamatórios
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Infarto do Miocárdio
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Ther
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Singapura