Targeting TGF-ß signaling for the treatment of fibrosis.
Matrix Biol
; 68-69: 8-27, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29355590
ABSTRACT
Transforming growth factor-ß (TGF-ß) is widely recognized as a core pathway of fibrosis. Inhibition of TGF-ß signaling may thus offer potential for antifibrotic therapies. Long-term inhibition of TGF-ß signaling at the level of its isoforms and receptors can be associated with unacceptable adverse effects. However, TGF-ß regulates a myriad of intracellular signaling cascades to transmit its profibrotic effects and several of those pathways offer potential for pharmacologic intervention. Moreover, the multiple interactions of TGF-ß with other profibrotic pathways also yielded candidates for therapeutic intervention. In this review, we discuss selected targets within the TGF-ß pathway with high translational potential.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrose
/
Transdução de Sinais
/
Fator de Crescimento Transformador beta
Limite:
Humans
Idioma:
En
Revista:
Matrix Biol
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Alemanha