Rotavirus hospitalizations among children <5â¯years of age-Tajikistan, 2013-2014.
Vaccine
; 36(51): 7794-7797, 2018 12 14.
Article
em En
| MEDLINE
| ID: mdl-29366710
ABSTRACT
BACKGROUND:
In January 2015, Tajikistan introduced the monovalent rotavirus vaccine into the national immunization program. Our objective was to estimate pre-vaccine burden of rotavirus-associated hospitalizations in children <5â¯years of age in Tajikistan.METHODS:
During January 2013-December 2014, active surveillance for acute gastroenteritis (AGE)-associated hospitalizations in children <5â¯years of age was conducted by sentinel surveillance site staff. Patients' demographic and clinical data were summarized and a stool sample was collected. An Enzyme Linked Immunosorbent Assay was used for diagnosis of rotavirus infection and subset of the specimens was sent for polymerase chain reaction (PCR) genotyping.RESULTS:
Of 2860 eligible children enrolled and tested, 1207 (42%) were positive for rotavirus. An increase in the number and proportion of rotavirus cases attributed to rotavirus season, with positivity rates >40%, was annually observed during June-September. The median age of rotavirus patients was 9â¯months and 939/1207 (78%) rotavirus patients were aged 6-23â¯months. Most (1097/1203; 91%) rotavirus patients were treated with intravenous fluids. G1P[8] was the predominant genotype during both years of surveillance, accounting for 133/222 (60%) of genotyped cases.CONCLUSION:
Rotavirus is a major cause of hospitalization due to severe AGE in children <5â¯years of age in Tajikistan, accounting for >40% of cases. Continued, enhanced rotavirus surveillance may allow documentation of changes in rotavirus disease burden following vaccine introduction and assessment of vaccine effectiveness.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Rotavirus
/
Programas de Imunização
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Vigilância de Evento Sentinela
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Hospitalização
Tipo de estudo:
Diagnostic_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
País/Região como assunto:
Asia
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2018
Tipo de documento:
Article