Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia.

Larsen, Malte Selch; Juul, Rasmus Vestergaard; Groth, Andreas Velsing; Simonsson, Ulrika S H; Kristensen, Annemarie T; Knudsen, Tom; Agersø, Henrik; Kreilgaard, Mads

Larsen, Malte Selch; Juul, Rasmus Vestergaard; Groth, Andreas Velsing; Simonsson, Ulrika S H; Kristensen, Annemarie T; Knudsen, Tom; Agersø, Henrik; Kreilgaard, Mads.

Afiliação

Larsen MS; Haemophilia PK & ADME, Haemophilia Research, Global Research, Novo Nordisk A/S, Maaloev, Denmark; Department of Veterinary Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark. Electronic address: xmtl@novonordisk.com.
Juul RV; Quantitative Clinical Pharmacology, Novo Nordisk A/S, Soeborg, Denmark.
Groth AV; Quantitative Clinical Pharmacology, Novo Nordisk A/S, Soeborg, Denmark.
Simonsson USH; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Kristensen AT; Department of Veterinary Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Knudsen T; Translational Haemophilia Pharmacology, Haemophilia Pharmacology, Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Agersø H; Quantitative Clinical Pharmacology, Novo Nordisk A/S, Soeborg, Denmark.
Kreilgaard M; Haemophilia PK & ADME, Haemophilia Research, Global Research, Novo Nordisk A/S, Maaloev, Denmark.

Eur J Pharm Sci ; 115: 196-203, 2018 Mar 30.

Article em En | MEDLINE | ID: mdl-29369801

Assuntos

Fator VIII/farmacocinética; Fator VIIa/farmacocinética; Hemofilia A/metabolismo; Animais; Área Sob a Curva; Cães; Feminino; Haplorrinos; Humanos; Masculino; Taxa de Depuração Metabólica/efeitos dos fármacos; Camundongos; Modelos Animais; Ratos; Proteínas Recombinantes/farmacocinética; Especificidade da Espécie

Palavras-chave

Allometric scaling; Coagulation factors; Interspecies; Pharmacokinetic modelling; Prediction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator VIII / Fator VIIa / Hemofilia A Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Eur J Pharm Sci Assunto da revista: FARMACIA / FARMACOLOGIA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article

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