Preferences for learning different types of genome sequencing results among young breast cancer patients: Role of psychological and clinical factors.
Transl Behav Med
; 8(1): 71-79, 2018 01 29.
Article
em En
| MEDLINE
| ID: mdl-29385583
ABSTRACT
The growing importance of genome sequencing means that patients will increasingly face decisions regarding what results they would like to learn. The present study examined psychological and clinical factors that might affect these preferences. 1,080 women diagnosed with breast cancer at age 40 or younger completed an online survey. We assessed their interest in learning various types of genome sequencing results:
risk of preventable disease or unpreventable disease, cancer treatment response, uncertain meaning, risk to relatives' health, and ancestry/physical traits. Multivariable logistic regression was used to examine whether being "very" interested in each result type was associated with clinical factors BRCA1/2 mutation status, prior genetic testing, family history of breast cancer, and psychological factors cancer recurrence worry, genetic risk worry, future orientation, health information orientation, and genome sequencing knowledge. The proportion of respondents who were very interested in learning each type of result ranged from 16% to 77%. In all multivariable models, those who were very interested in learning a result type had significantly higher knowledge about sequencing benefits, greater genetic risks worry, and stronger health information orientation compared to those with less interest (p-values < .05). Our findings indicate that high interest in return of various types of genome sequencing results was more closely related to psychological factors. Shared decision-making approaches that increase knowledge about genome sequencing and incorporate patient preferences for health information and learning about genetic risks may help support patients' informed choices about learning different types of sequencing results.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Testes Genéticos
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Predisposição Genética para Doença
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Preferência do Paciente
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Comunicação em Saúde
Tipo de estudo:
Prognostic_studies
/
Qualitative_research
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Transl Behav Med
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos