P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling.

Wang, Le; Zhan, Xiangwen; Shen, Xiaomeng; Li, Mingzhe; Yang, Jianming; Yu, Wenhua; Chen, Hao; Jin, Bo; Mao, Zebin

Wang, Le; Zhan, Xiangwen; Shen, Xiaomeng; Li, Mingzhe; Yang, Jianming; Yu, Wenhua; Chen, Hao; Jin, Bo; Mao, Zebin.

Afiliação

Wang L; The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
Zhan X; The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
Shen X; The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
Li M; The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
Yang J; The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
Yu W; The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
Chen H; The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
Jin B; Department of Clinical Laboratory, Peking University First Hospital, 8 Xishiku Road, Beijing, 100034, China. jinbo@bjmu.edu.cn.
Mao Z; The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100191, China. zbmao@bjmu.edu.cn.

Mol Cell Biochem ; 446(1-2): 137-148, 2018 Sep.

Article em En | MEDLINE | ID: mdl-29388151

Assuntos

Neoplasias da Mama/metabolismo; Movimento Celular; Proliferação de Células; Inibidor p16 de Quinase Dependente de Ciclina/metabolismo; Interleucina-6/metabolismo; Janus Quinase 2/metabolismo; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais; Animais; Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Inibidor p16 de Quinase Dependente de Ciclina/genética; Feminino; Xenoenxertos; Humanos; Interleucina-6/genética; Janus Quinase 2/genética; Células MCF-7; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Transplante de Neoplasias; Fator de Transcrição STAT3/genética

Palavras-chave

Breast cancer; Interleukin 6 signal transducer; P16; STAT3; Short hairpin RNA

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transdução de Sinais / Movimento Celular / Interleucina-6 / Inibidor p16 de Quinase Dependente de Ciclina / Proliferação de Células / Fator de Transcrição STAT3 / Janus Quinase 2 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Mol Cell Biochem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google