Underperformance of Mediastinal Lymph Node Evaluation in Resectable Non-Small Cell Lung Cancer.
Ann Thorac Surg
; 105(3): 943-949, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29397099
ABSTRACT
BACKGROUND:
Mediastinal lymph node evaluation (MLNE) is considered to be the standard of care in curative lung cancer surgery although it is not always performed. This study identifies factors associated with patients not being evaluated (non-MLNE) in cases of resectable non-small cell lung cancer.METHODS:
A retrospective observational study using the Surveillance, Epidemiology, and End Results Program database was conducted. Adult patients diagnosed with non-small cell lung cancer stage I to IIIA (2004 to 2013) were included. Multilevel logistic regression analysis was performed to identify factors that were associated with non-MLNE.RESULTS:
There were 86,721 patients included in this study 73,034 (84.2%) with MLNE and 13,687 (15.8%) without. The use of MLNE gradually increased from 82.7% in 2004 to 85.8% in 2013. In multivariable analysis, factors associated with non-MLNE included the following age more than 75 years (adjusted odds ratio [ORadj] 1.20, 95% confidence interval [CI] 1.13 to 1.27); black (ORadj 1.11, 95% CI 1.32 to 1.20); Native American/Alaskan (ORadj 1.63, 95% CI 1.15 to 2.31); uninsured (ORadj 1.28, 95% CI 1.05 to 1.56); residing in a low-income county (ORadj 1.12, 95% CI 1.04 to 1.21); lesion at the middle lobe (ORadj 1.42, 95% CI 1.29 to 1.56); lower lobe (ORadj 1.06, 95% CI 1.01 to 1.11) or main bronchus (ORadj 2.38, 95% CI 1.93 to 2.94); stage IA (ORadj 1.24, 95% CI 1.17 to 1.32); sublobar resection (ORadj 11.08, 95% CI 11.30 to 12.33); and preoperative treatment (ORadj 1.21, 95% CI 1.08 to 1.36). Non-MLNE was less likely to occur in patients with adenocarcinoma (ORadj 0.88, 95% CI 0.83 to 0.92) and more likely in other cell types (ORadj 1.23, 95% CI 1.15 to 1.32), compared with squamous cell carcinoma.CONCLUSIONS:
Patient demographics and socioeconomic status are associated with the decision to perform MLNE. Thoracic surgeons should access these factors and perform MLNE to accurately determine tumor stage and improve survival.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
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Excisão de Linfonodo
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Ann Thorac Surg
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Tailândia