HIPK2 polymorphisms rs2058265, rs6464214, and rs7456421 were associated with kidney stone disease in Chinese males not females.
Gene
; 653: 51-56, 2018 May 05.
Article
em En
| MEDLINE
| ID: mdl-29428801
ABSTRACT
BACKGROUND AND AIM:
Recent studies have shown that genetic factors are involved in the development of kidney stone disease (KSD). A case-control association analysis was performed to investigate the association between homeodomain-interacting protein kinase 2 (HIPK2; OMIM *606868) polymorphisms and KSD.METHODS:
A total of 890 KSD patients and 920 healthy subjects were analyzed. Polymorphisms were genotyped using SNPscanTM high-throughput SNP classification technology. The genotypic and allelic frequencies in KSD patients and healthy individuals were analyzed using a Chi-square test.RESULTS:
The genotype and allele distributions of the three polymorphisms (rs2058265, rs6464214, and rs7456421 in HIPK2) displayed strong associations with KSD in males (rs2058265 odds ratio [OR] 2.480,95%confidence interval [CI] 1.205-5.106, pâ¯=â¯0.014; rs6464214 OR 2.466, 95%CI 1.198-5.078, pâ¯=â¯0.014; rs7456421 OR 2.846, 95%CI 1.362-5.947, pâ¯=â¯0.005; perallele r2058265T, OR 1.357, 95%CI 1.073-1.715, pâ¯=â¯0.011; rs6464214G, OR 1.340, 95%CI 1.060-1.693, pâ¯=â¯0.014; rs7456421C, OR 1.356, 95%CI 1.073-1.713, pâ¯=â¯0.011). Patients carrying the T allele of rs2058265, the G allele of rs6464214, or the C allele of rs7456421 showed higher systolic blood pressure, creatinine, and uric acid levels compared with wild-genotype individuals after adjusting for age, gender, and body mass index (pâ¯<â¯0.005).CONCLUSION:
The association of HIPK2 gene polymorphisms with KSD was only observed in males but not in females. HIPK2 gene polymorphisms were also involved in the changes of KSD-related metabolic traits.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Cálculos Renais
/
Fatores Sexuais
/
Proteínas Serina-Treonina Quinases
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Gene
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China