Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes.

Lakhter, Alexander J; Pratt, Rachel E; Moore, Rachel E; Doucette, Kaitlin K; Maier, Bernhard F; DiMeglio, Linda A; Sims, Emily K

Lakhter, Alexander J; Pratt, Rachel E; Moore, Rachel E; Doucette, Kaitlin K; Maier, Bernhard F; DiMeglio, Linda A; Sims, Emily K.

Afiliação

Lakhter AJ; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.
Pratt RE; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA.
Moore RE; Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Doucette KK; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.
Maier BF; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA.
DiMeglio LA; Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Sims EK; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.

Diabetologia ; 61(5): 1124-1134, 2018 05.

Article em En | MEDLINE | ID: mdl-29445851

Assuntos

Biomarcadores/metabolismo; Citocinas/metabolismo; Diabetes Mellitus Tipo 1/metabolismo; Células Secretoras de Insulina/metabolismo; MicroRNAs/genética; Animais; Apoptose; Vesículas Extracelulares; Feminino; Perfilação da Expressão Gênica; Humanos; Inflamação; Interleucina-1beta/metabolismo; Camundongos; Camundongos Endogâmicos NOD; MicroRNAs/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Beta cell signal transduction; Cell lines; Human; Prediction and prevention of type 1 diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Citocinas / MicroRNAs / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Diabetologia Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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