Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3KÎ³ isoform selective activity.

Srinivas, M; Singh Pathania, Anup; Mahajan, Priya; Verma, Praveen K; Chobe, Santosh S; Malik, Fayaz A; Nargotra, Amit; Vishwakarma, Ram A; Sawant, Sanghapal D

Srinivas, M; Singh Pathania, Anup; Mahajan, Priya; Verma, Praveen K; Chobe, Santosh S; Malik, Fayaz A; Nargotra, Amit; Vishwakarma, Ram A; Sawant, Sanghapal D.

Afiliação

Srinivas M; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India.
Singh Pathania A; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India.
Mahajan P; Discovery Informatics Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India.
Verma PK; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India.
Chobe SS; Department of Chemistry, Loknete Vyankatrao Hiray Arts, Science and Commerce College, Nashik (M.S.), India.
Malik FA; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India.
Nargotra A; Discovery Informatics Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India.
Vishwakarma RA; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India.
Sawant SD; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India. Electronic address: sdsawant@iiim.ac.in.

Bioorg Med Chem Lett ; 28(6): 1005-1010, 2018 04 01.

Article em En | MEDLINE | ID: mdl-29486969

Assuntos

Antineoplásicos/farmacologia; Desenho de Fármacos; Inibidores de Fosfoinositídeo-3 Quinase; Inibidores de Proteínas Quinases/farmacologia; Quinazolinonas/farmacologia; Triazóis/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Classe Ib de Fosfatidilinositol 3-Quinase/metabolismo; Reação de Cicloadição; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Estrutura Molecular; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Quinazolinonas/síntese química; Quinazolinonas/química; Relação Estrutura-Atividade; Triazóis/síntese química; Triazóis/química

Palavras-chave

1H-1,2,3-Triazolo-quinazolin-4(3H)-ones; Huisgen 1,3-dipolar cycloaddition; Multicomponent synthesis; PI3K-Î³ inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Desenho de Fármacos / Inibidores de Proteínas Quinases / Quinazolinonas / Inibidores de Fosfoinositídeo-3 Quinase / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia

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