Non-invasive estimation of <sup>10</sup> B-4-borono-L-phenylalanine-derived boron concentration in tumors by PET using 4-borono-2-<sup>18</sup> F-fluoro-phenylalanine.

Yoshimoto, Mitsuyoshi; Honda, Natsuki; Kurihara, Hiroaki; Hiroi, Kenta; Nakamura, Satoshi; Ito, Masashi; Shikano, Naoto; Itami, Jun; Fujii, Hirofumi

Non-invasive estimation of ¹⁰ B-4-borono-L-phenylalanine-derived boron concentration in tumors by PET using 4-borono-2-¹⁸ F-fluoro-phenylalanine.

Yoshimoto, Mitsuyoshi; Honda, Natsuki; Kurihara, Hiroaki; Hiroi, Kenta; Nakamura, Satoshi; Ito, Masashi; Shikano, Naoto; Itami, Jun; Fujii, Hirofumi.

Afiliação

Yoshimoto M; Division of Functional Imaging, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.
Honda N; Department of Pharmacy, National Cancer Center Hospital, Tokyo, Japan.
Kurihara H; Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
Hiroi K; Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
Nakamura S; Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
Ito M; Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
Shikano N; Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ami, Ibaraki, Japan.
Itami J; Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
Fujii H; Division of Functional Imaging, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.

Cancer Sci ; 109(5): 1617-1626, 2018 May.

Article em En | MEDLINE | ID: mdl-29498142

Assuntos

Compostos de Boro/farmacocinética; Terapia por Captura de Nêutron de Boro/métodos; Fenilalanina/análogos & derivados; Tomografia por Emissão de Pósitrons/métodos; Animais; Linhagem Celular Tumoral; Feminino; Humanos; Infusões Intravenosas; Camundongos; Camundongos Endogâmicos BALB C; Fenilalanina/farmacocinética; Distribuição Tecidual

Palavras-chave

10B-4-borono-L-phenylalanine; 4-borono-2-18F-fluoro-phenylalanine; L type amino acid transporter; PET; boron neutron capture therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilalanina / Compostos de Boro / Terapia por Captura de Nêutron de Boro / Tomografia por Emissão de Pósitrons Limite: Animals / Female / Humans Idioma: En Revista: Cancer Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão

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