TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma.

Itoh, Hitoshi; Kadomatsu, Tsuyoshi; Tanoue, Hironori; Yugami, Masaki; Miyata, Keishi; Endo, Motoyoshi; Morinaga, Jun; Kobayashi, Eisuke; Miyamoto, Takeshi; Kurahashi, Ryoma; Terada, Kazutoyo; Mizuta, Hiroshi; Oike, Yuichi

Itoh, Hitoshi; Kadomatsu, Tsuyoshi; Tanoue, Hironori; Yugami, Masaki; Miyata, Keishi; Endo, Motoyoshi; Morinaga, Jun; Kobayashi, Eisuke; Miyamoto, Takeshi; Kurahashi, Ryoma; Terada, Kazutoyo; Mizuta, Hiroshi; Oike, Yuichi.

Afiliação

Itoh H; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Kadomatsu T; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Tanoue H; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. tkado@gpo.kumamoto-u.ac.jp.
Yugami M; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Miyata K; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Endo M; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Morinaga J; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Kobayashi E; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Miyamoto T; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Kurahashi R; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Terada K; Center for Clinical Research, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Mizuta H; Department of Nephrology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Oike Y; Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8525, Japan.

Oncogene ; 37(22): 2903-2920, 2018 05.

Article em En | MEDLINE | ID: mdl-29515232

Assuntos

Neoplasias Ósseas/patologia; Metilação de DNA; Proteínas de Ligação a DNA/metabolismo; Interleucina-6/genética; Neoplasias Pulmonares/patologia; Neoplasias Pulmonares/secundário; Osteossarcoma/patologia; Proteínas Proto-Oncogênicas/metabolismo; Animais; Neoplasias Ósseas/genética; Neoplasias Ósseas/metabolismo; Linhagem Celular Tumoral; Proteínas de Ligação a DNA/genética; Dioxigenases; Epigênese Genética; Regulação Neoplásica da Expressão Gênica; Técnicas de Silenciamento de Genes; Humanos; Molécula 1 de Adesão Intercelular/genética; Interleucina-6/metabolismo; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Sistema de Sinalização das MAP Quinases; Camundongos; Transplante de Neoplasias; Osteossarcoma/genética; Osteossarcoma/metabolismo; Proteínas Proto-Oncogênicas/genética; Microambiente Tumoral; Regulação para Cima

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / Proteínas Proto-Oncogênicas / Interleucina-6 / Metilação de DNA / Proteínas de Ligação a DNA / Neoplasias Pulmonares Limite: Animals / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão

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