Early paracetamol exposure decreases brain-derived neurotrophic factor (BDNF) in striatum and affects social behaviour and exploration in rats.
Pharmacol Biochem Behav
; 168: 25-32, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29545027
ABSTRACT
The biochemical and behavioral responses to prenatal and early postnatal exposure to paracetamol in rats are not well understood. The effect of daily maternal and early life administration of 5â¯mg/kg (group P5) or 15â¯mg/kg paracetamol (group P15) was evaluated in two-month old male rats, relative to control animals receiving tap water (Con). Social behavior and episodic memory were investigated with Social Interaction and Novel Object Recognition (NOR) tests. Quantification of brain-derived neurotrophic factor (BDNF) was determined in prefrontal cortex, hippocampus and striatum using enzyme-linked immunosorbent assay (ELISA). Control animals exhibited a higher total frequency of social interactions and greater frequency of sniffing compared to rats exposed to paracetamol, and we found a statistically significant increase in the occurrence of pinning in paracetamol-treated animals. Rats from the 15â¯mg/kg group exhibited a greater interest in objects in the NOR test and spent more time exploring objects during the familiarization and choice phases. Biochemical analysis showed significant differences in striatal BDNF between the groups, specifically, a nearly two-fold decrease in striatal BDNF in the paracetamol groups (P5 6.78⯱â¯0.60â¯pg/mg; P15 6.06⯱â¯0.46â¯pg/mg) relative to the control group (Con 11.33⯱â¯2.00â¯pg/mg). These results indicate that paracetamol exposure induces changes in social behaviour and exploration in rats and results in a significant decrease of striatal BDNF.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Social
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Comportamento Animal
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Exposição Materna
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Analgésicos não Narcóticos
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Fator Neurotrófico Derivado do Encéfalo
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Corpo Estriado
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Comportamento Exploratório
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Acetaminofen
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Pharmacol Biochem Behav
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Polônia