Mortality causes and trends associated with giant cell arteritis: analysis of the French national death certificate database (1980-2011).
Rheumatology (Oxford)
; 57(6): 1047-1055, 2018 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-29554340
ABSTRACT
OBJECTIVES:
Comprehensive analyses of cause-specific death patterns in GCA are sparse. We studied the patterns and time trends in GCA-related mortality using a large death certificate database.METHODS:
We obtained multiple-cause-of-death data from the French national death certificate database for 1980-2011. GCA-associated deaths were defined as decedents ⩾55 years old with GCA listed as an underlying or non-underlying cause of death. Time trends of death rates were analysed and the mean age at death with GCA and in the general population ⩾55 years old were calculated. Standardized mortality odds ratios (SMORs) were calculated for 17 selected causes of death (based on 2000-11 data).RESULTS:
The analyses pertained to approximately 15 000 death certificates listing GCA (including approximately 6300 for 2000-11). Annual standardized death rates for GCA increased to a peak in 1997 and then decreased (Spearman's correlation test, both P < 0.0001). Mean age at death was higher for GCA than for general population decedents (Student's t-test, P < 0.0001). GCA deaths were frequently or strongly associated with aortic aneurysm and dissection (1.85% of death certificates, SMOR 3.09, 95% CI 2.48, 3.82), hypertensive disease (20.78%, SMOR 2.22, 95% CI 1.97, 2.50), diabetes mellitus (11.27%, SMOR 1.96, 95% CI 1.72, 2.23), certain infectious and parasitic diseases (12.12%, SMOR 1.76, 95% CI 1.55, 2.00) and ischaemic heart disease (16.54%, SMOR 1.45, 95% CI 1.35, 1.64).CONCLUSION:
GCA is associated with increased risk of dying from large-vessel disease, other cardiovascular diseases and potentially treatment-related co-morbidities. These findings help provide better insights into the outcomes of GCA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arterite de Células Gigantes
/
Doenças Cardiovasculares
/
Sistema de Registros
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Atestado de Óbito
/
Neoplasias
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Rheumatology (Oxford)
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França