Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease.

Stahl, Katja; Rahmani, Soulmaz; Prydz, Agnete; Skauli, Nadia; MacAulay, Nanna; Mylonakou, Maria N; Torp, Reidun; Skare, Øivind; Berg, Torill; Leergaard, Trygve B; Paulsen, Ragnhild E; Ottersen, Ole P; Amiry-Moghaddam, Mahmood

Stahl, Katja; Rahmani, Soulmaz; Prydz, Agnete; Skauli, Nadia; MacAulay, Nanna; Mylonakou, Maria N; Torp, Reidun; Skare, Øivind; Berg, Torill; Leergaard, Trygve B; Paulsen, Ragnhild E; Ottersen, Ole P; Amiry-Moghaddam, Mahmood.

Afiliação

Stahl K; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Rahmani S; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Prydz A; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Skauli N; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
MacAulay N; Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mylonakou MN; Centre for Molecular Medicine Norway, Nordic EMBL Partnership, Norway Biotechnology Centre, University of Oslo, Oslo, Norway.
Torp R; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Skare Ø; Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway.
Berg T; Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Leergaard TB; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Paulsen RE; Department of Pharmaceutical Sciences, School of Pharmacy, University of Oslo, Oslo, Norway.
Ottersen OP; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Amiry-Moghaddam M; Karolinska Institutet, Stockholm, Sweden.

PLoS One ; 13(3): e0194896, 2018.

Article em En | MEDLINE | ID: mdl-29566083

Assuntos

Aquaporinas/genética; Neuroproteção/genética; Doença de Parkinson/genética; Doença de Parkinson/patologia; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina/farmacocinética; Animais; Modelos Animais de Doenças; Neurônios Dopaminérgicos/efeitos dos fármacos; Neurônios Dopaminérgicos/metabolismo; Feminino; Deleção de Genes; Células HEK293; Humanos; Intoxicação por MPTP/genética; Intoxicação por MPTP/metabolismo; Intoxicação por MPTP/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mutagênese Sítio-Dirigida; Fármacos Neuroprotetores/metabolismo; Doença de Parkinson Secundária/induzido quimicamente; Doença de Parkinson Secundária/genética; Doença de Parkinson Secundária/metabolismo; Doença de Parkinson Secundária/patologia; Substância Negra/efeitos dos fármacos; Substância Negra/metabolismo; Xenopus laevis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Aquaporinas / Neuroproteção Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Noruega

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